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Minimum Dosing Interval: every 4 hours. amoxicillin 500mg dosage Maximum Dose: 75 mg/kg per 24 hours Oral: Immediate-release: 325 mg to 1 g orally every 4 to 6 hours Minimum Dosing Interval: every 4 hours Maximum Single Dose: 1000 mg Maximum Dose: 4 g per 24 hours Extended-Release: 1300 mg orally every 8 hours