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Metamizole works in a similar way as NSAIDs, but is not classified as an NSAID. paracetamol mef 500 mg Metamizole is from the ampyrone sulfonate family of medicines Metamizole Dosage The typical adult dosage of dipyrone is 500 mg to 1,000 mg by mouth, taken 2 to 3 times daily It is also available for intravenous (IV), intramuscular (IM) or rectal administration